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Par-4 antisense oligonucleotide antagonist of glutamate on PC12 cells, phosphorylation of protein kinase Akt1 down effect and significance of anti-apoptosis

Break down resistance to the oligonucleotide (Wai 1) 3. Qian par-4 antisense nucleotide House on glutamate induced PC12 cell apoptosis: flow cytometry analysis. Apoptotic death induced by glutamate group mortgage percentage 55kDP-h1 (6OkD) 234567 ... Lu mother; l: protein points to the amount of M ~ rker; 2: normal on the use of group; 3: A group of acid-induced apoptosis; 4 : P4 edge nucleotide oligonucleotide against the history of the intervention group; 5: par-* scrambled past Eucalyptus acid control; 6: liposome control maggots: 7: p antisense nucleotide + PI3K/AktJ blocker LY29 ~ G02 group of dry lap lW ~ tembiol hit electrophoresis March 2005 Volume 43 No. 3 ChloJPediatr, March2O05Vol43No3 rate was 52%,[link widoczny dla zalogowanych], 10 ~, mol/Lpar4 prepared antisense oligonucleotides antagonize acid-induced apoptosis,[link widoczny dla zalogowanych], poke the percentage dropped to 31% of death,[link widoczny dla zalogowanych], the difference was statistically significant (P (0O1). If I PI3K/Akt,[link widoczny dla zalogowanych], LY294002 inhibitor pretreatment, then the antagonism is down, stabbed dead percentage 41% (P <005 ). This shows that the par-4 antisense nucleotide edge effect of the anti-stab death, at least in part Akt. dependent discuss par-d-gene is a recent study found when the prostate cancer cells were par4 protein from the 342 ... amino acids. through its C terminal leucine zipper, par-4 interaction with aPKCs other signaling molecules, to play its role in apoptosis; recent data show that par .. 4 involved, and the Bureau of global ischemia the pathogenesis of focal cerebral ischemia... Upon results showed. PCI2 glutamate in the induction of apoptosis, but also increased protein levels induced by par4. This confirms pBr4 glutamate may be involved in apoptosis of machine hood. using antisense oligonucleotide inhibits pm'-4 gene expression at the same time, PCI2 cells induced by glutamate Bute on the role of power is inhibited apoptosis. This shows that p ~ r-4 antisense oligonucleotide can be antagonistic character of nitrogen acid induced death of PC12 cells poke. We found that glutamate can induce phosphorylation of PCI2 cells (Thr308) of Akt down, while transfection of antisense oligonucleotide _4 selection can be significantly under the effect of inhibition of blame . If I PI3K/Akt antagonist. the par-4 antisense oligonucleotide on apoptosis induced by glutamate antagonism is a certain degree of reduction. This shows that, par-4 antisense oligonucleotide the role of anti-stab death, at least in part AktI dependent protein kinase Akt, also known as B (proteinkinaseB, PKB), the phosphatidylinositol 3 kinase (phosphoinc ~ itide3kinase, PI3K) / Akt signal transduction to occupy the core of the road. Akt phosphorylation (Thr308), the anti-apoptotic effect of promoting the survival mainly through inhibition of its downstream easp ~ e family members, BAD and so the role of signaling molecules produced. The results indicated that par-4 antisense oligonucleotide the role of acid has anti-Si-die, the anti-apoptotic mechanism may be Akt. phosphorylation
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