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bcl-6, CD10 and CD38 immunoreactivity in stage Ⅰ, Ⅱ and prognostic significance of gastric lymphoma

l, which has biological activity, longer half-life can be extended treatment duration. (Liu Kang Abstract) be1.6,[link widoczny dla zalogowanych], CD10 and CD38 immunoreactivity in the I, Ⅱ and prognostic significance of gastric lymphoma [English] / PonzoniM, FerreriAI, PruneriG, etal / / IntJCancer. 2003,106 (2) :2651 -2656 gastric non-Hodgkin's lymphoma of the most common occurrence of extranodal sites, originating in the gastric lymphoma (PGL) histologic heterogeneity of large, low or high malignant patients treatment should be very different. Although the prognostic factors for the choice of treatment strategy on the growing role of the guidance, but for the PGL, in particular the total accounted for 2 / 3 of the large cell lymphoma (LCL) have not found a clear prognosis. According to the different molecular genetic lymphoma, LCL is divided into germinal center B cell-like and activated B cell-like two categories,[link widoczny dla zalogowanych], bc16, CD10 and CD38 expression on the former more than could be identified and prognosis of these two molecules are different diffuse LCL very useful markers. Therefore, the observed bcl a 6, CD10 and CD38 in the I, Ⅱ in the immune activity of PGL and its clinical significance. 102 cases of adult B cells in patients with PGL, the median age was 63 (28 ~ 89) years, male: female was 1.1:1. By operation and histological examination of 55 cases I, Ⅱ A on 39 cases, Ⅱ B of 8 cases. 41 cases of low grade marginal zone B cell lymphoma (LGML), 30 cases of diffuse large cell lymphoma (DLCL), 31 cases of DLCL combined LGML (DLCML). 44 patients were treated without surgery, 16 patients were median 40Gy of radiotherapy, 42 patients receiving chemotherapy. Application of bcl a 6, CD10 and CD38 monoclonal antibodies for immunohistochemical analysis. Observed indicators of immune activity (IR) distribution and clinical features such as time to disease progression (1vrP), overall survival (os) and so the correlation between. Results: ① 7 例 (17%) LGML, 15 例 (48%) DLCML and 15 cases (50%) DLCL showed typical nuclear bc16IR (P = 0.0002). It is noteworthy that, LGML in diffuse large cell bc16IR than small malignant cells; DLCL 6 cells in a proportion of bcl significantly higher than LGML. ② CD10IR only found in 8 cases (26%) DLCML and 8 cases (27%) DLCL (P = 0.0004); 13% LGML, 48% DLCML and 45% DLCL showed CD38IR (P = 0.005), while CD38 is not only can be colored in the tumor cells and plasma cell membrane, but also can be dyed LGML residual reactive germinal center cells. ③ In LGLM patients, bc16IR, CD38IR and 5-year OS and disease outcome was no significant correlation, multivariate analysis, the decision stage of the disease in patients with the disease outcome is the only independent prognostic factors. In LCL patients, CD10IR significantly associated with 1vrP and oS (P = 0.04), while bcl one 6IR, CD38IR irrelevant; in DLCL and DLCML of the independent analysis of further evidence of Cox's CD10IR prognostic role. Age, the application of chemotherapy, LDH ratio and also contain low-grade ingredients are all independent prognostic factors for long-term survival. DLC-ML 5-year oS patients is significantly higher than DLCL patients (P = 0.04). However, the DLCL CD10 was significantly higher than in patients with 5-year oS DLCML and CD10 in DLCL patients (P = 0.01). Conclusion: CD10IR can be found in more than 50% of the LCL, which is not seen in LGML CD10IR, tips CD10 can be used for low-grade gastric lymphoma diagnosis. The bc1.6 and first studied in the PGL cD38, although predominantly expressed in the LCL, but can not effectively predict disease outcome. (ELECTRIC & Abstract)
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