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Hypoxic ischemic encephalopathy in preterm children the diagnosis and treatment - hypoxic-ischemic encephalopathy in preterm children how to diagnose and treat?

21, E: 0.002, lymphocytes were significantly higher (0.778) to mature small lymphocytes mainly to reduce the ratio of granulocyte,[link widoczny dla zalogowanych], late the following stages were significantly reduced immature, some of coarse particles in the cytoplasm, showing that dual-core naive granulocyte; erythroid ratio was significantly lower, mature red blood cells vary in size, color filling poor; the entire film, see 79 giant cells, and scattered piles of platelets can be seen (Figure 1-3). Immunophenotyping of bone marrow cells: CD, as 0.069, CD3 is 0.084, CD4 is 0.034, CD5 was 0.514, CD7 was 0.031, CD10 was 0.024, CD19 was 0.754, CD20 is 0.380, CD is 0, CD 0, diagnosed with chronic lymphocytic leukemia. Follow-up since 1 year and 9 months, children generally good, no fever, anemia, bleeding, infection, joint pain and other signs of peripheral WBC in the (57-290) × 10 '/ L, between the lymphocyte predominance (85%), Hb fluctuations in the 78-97g / L between, PLT normal. Referral to our hospital 3 times, not superficial lymph nodes, liver,[link widoczny dla zalogowanych], ribs 1cm, spleen and ribs 7cm, texture medium, no tenderness. Discussion: Chronic lymphocytic leukemia (CLL) occur in the elderly, average age 60-70 years, the incidence was higher than that of Western countries, the age of 50 the number of disease incidence by 11% of the total, 40 persons under the age of onset 1.5% 13, infant morbidity is extremely rare. CLL tumor cells are mainly B cells,[link widoczny dla zalogowanych], surface immunoglobulin (Smlg) was weakly positive, with IgM and the D-main, and was a single light chain (- (or chain). These cells also expressed T fine of Unit: 450052 of Pediatrics, First Affiliated Hospital of Zhengzhou University. case report. cell-associated antigen CD, human leukocyte antigen DR (HLA-DR) and the B cell antigen CD.. and the CD. CLL patients with a large number of peripheral blood lymphocytes in G0 and more period, cell proliferation index is low, so the proliferation of CLL is not a disease, but because of programmed cell death was inhibited, the survival time of a large number of cells caused by the accumulation of long. CLL clinical manifestations of lymph nodes and liver, splenomegaly, infiltration of other organs such as the lung parenchyma, pleura, gastrointestinal mucosa and other rare. laboratory examination of peripheral blood white blood cell count was significantly increased in lymphocyte-based. lymphocyte count at least (5 ~ 10) × 10 '/ L or more, mostly in the (40 ~ 150 ) × 10 '/ L, between a few cases up to 500 × 10' / L. morphology similar to normal lymphocytes, advanced disease can be seen a small amount of abnormal large lymphocytes, and nucleoli. about 10% to 15% of cases may have hemoglobin and thrombocytopenia, Coombs test was positive in 20% of cases, and hemolytic anemia is rare. The diagnosis should be such as EB virus infectious disease, tuberculosis,[link widoczny dla zalogowanych], Toxoplasma gondii, cytomegalovirus infection caused an increase in differentiated cells. common infections disease patients have significant symptoms, lymphocyte count rare than 15 × 10 '/ Ll2.3j. in this case 1 year 5 months that Congress and the white blood cells found in the spleen increased, laboratory tests and 2 years and 9 months of the course infectious diseases can be excluded due to an increase in lymphocytes. Other cases of chronic lymphoproliferative diseases, such as prolymphocytic leukemia, hairy cell leukemia, macroglobulinemia, and so easy to be confused with CLL. However, the clinical manifestations of these diseases and the characteristics of tumor cells has its own characteristics. The disease is closely related to prognosis and disease stage, in the d, JL The prognosis needs further observation. (see Figure 1-3 This illustration 12-2)
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